AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS

Background: Amyotrophic lateral sclerosis (ALS) is a rare chronic degenerative disease. The only approved treatment, Riluzole, not available and economically affordable for most patients. Objective: To report here case of pregnant woman 27 years age with ALS, confirmed through electromyography. After spontaneous abortion 88 days without clinical improvement dependent on mechanical ventilation, treatment autologous stem cell transplantation immunomodulation was decided upon the patient. Methods: patient received daily subcutaneous (s.c.) dose 300 μg human Granulocyte-Colony stimulating factor period 3 days. Peripheral blood mononuclear cells were isolated by leukapheresis. These self-transplanted to 5 cc via lumbar puncture intravenously (i.v.). based surface-fixation method. Results: remained hospitalized an additional 249 days, at which time when she contrareferred secondary-level health institution. Conclusion: A scheme combining ASCT (Autologous Stem Cell Transplantation) immunomodulation, method, could be option get large no progression stage in ALS.